Preparation and Enantioseparation of Biselector Chiral Stationary Phases Based on Amylose and Chitin Derivatives

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Preparation and Enantioseparation of Biselector Chiral Stationary Phases Based on Amylose and Chitin Derivatives.

Amylose derivatives chiral stationary phases (CSPs), some of which are commercially available, are well known for their powerful enantioseparation performance. However, due to the dissolution or swelling properties of amylose derivatives, this type of CSPs prepared by coating method exhibit poor solvent tolerance and stability. In order to overcome the defect as well as maintain the chiral reco...

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Review High-performance liquid chromatographic enantioseparation of drugs containing multiple chiral centers on chiral stationary phases

In recent years there has been considerable interest in the synthesis and separation of enantiomers of organic compounds especially because of their importance in the biochemistry and pharmaceutical industry. High-performance liquid Chromatography is a very useful method for the direct separation of enantiomers. However, about 30−40 years ago, commercially available chiral stationary phases wer...

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Enantioseparation using amylose esters as chiral stationary phases for high-performance liquid chromatography

Novel amylose ester derivatives were synthesized and their chiral recognition abilities as chiral stationary phases for highperformance liquid chromatography were evaluated. Compared with amylose benzoate derivatives, cinnamate derivatives showed a higher chiral recognition ability and some racemates could be efficiently resolved. The recognition abilities of these derivatives varied significan...

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review high-performance liquid chromatographic enantioseparation of drugs containing multiple chiral centers on chiral stationary phases

in recent years there has been considerable interest in the synthesis and separation of enantiomers of organic compounds especially because of their importance in the biochemistry and pharmaceutical industry. high-performance liquid chromatography is a very useful method for the direct separation of enantiomers. however, about 30−40 years ago, commercially available chiral stationary phases wer...

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Normal-phase HPLC enantioseparation of novel chiral metal tetrahedrane-type clusters on an amylose-based chiral stationary phase.

In the present work, an amylose tris(3,5-dimethylphenylcarbamate) (ADMPC) chiral stationary phase (CSP) was prepared by coating ADMPC on small-particle silica gel. This ADMPC-CSP was for the first time successfully applied to separate a series of novel chiral metal tetrahedrane-type clusters. Furthermore, the influence of a mobile-phase modifier (various alcohols added in the mobile phase), inc...

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ژورنال

عنوان ژورنال: Analytical Sciences

سال: 2015

ISSN: 0910-6340,1348-2246

DOI: 10.2116/analsci.31.1091